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COVID-19-related Disruptions
April 03, 2020
Due to the current situation with COVID-19, we are operating with reduced staffing and there may be delays in responding to emails and phone calls at this time. In addition, because of institutional restrictions and uncertainty with courier services, the MMRRC is currently shipping or receiving live animals on a case-by-case basis. Please contact us to discuss your needs. For ongoing orders, we will continue to communicate frequently to keep you apprised of the status of your order. Thank you for understanding.
New MUMC Website!
The MU Metagenomics Center recently launched a new website – please visit us at:
http://mumc.missouri.edu
April 06, 2015
The MU Metagenomics Center recently launched a new website – please visit us at:
http://mumc.missouri.edu
Watch the video!
Microbiota Characterization
The gut microbiota (GM) is now recognized as a key factor in health and disease. Differences in the composition of the gut microbiota of research animals may contribute to altered phenotypes or poor reproducibility of animal-based studies. Culture-independent techniques such as next-generation sequencing (NGS) allow in-depth characterization of the gut microbiota. The MMRRC now offers a full line of NGS-related services including fecal DNA extraction, 16S rDNA gene sequencing, and informatics analysis to researchers using mouse models. For more information, please see here or contact mmrrc@missouri.edu.
Please visit
MU METAGENOMICS CENTER (MUMC)
April 02, 2015
Please visit
MU METAGENOMICS CENTER (MUMC)
Journal of the Missouri State Medical Association
June 01, 2013
SCIENCE OF MEDICINE
One Medicine: Collaborative Research on Human & Animal Disease for the Betterment of Both
Craig L. Franklin, DVM, PhD .......... 195
A Brief History of Animal Modeling
Aaron C. Ericsson, DVM, PhD, Marcus J. Crim, DVM & Craig L. Franklin, DVM, PhD .......... 201
New York Times Article Misleads on the Value of Mouse Models
Catherine E. Hagan, DVM, PhD .......... 206
The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research
Elizabeth C. Bryda, PhD .......... 207
The Laboratory Animal Veterinarian: More than just a Mouse Doctor
Cynthia G. Alvarado, DVM & Lonny M. Dixon, DVM .......... 223
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Publications
- Euthanasia Via CO2 Inhalation Causes Premature Cortical Granule Exocytosis in Mouse Oocytes and Influences in-vitro Fertilization and Embryo Development. Wuri L, Agca C, Agca Y (2019). Mol. Reprod. Dev. (in press).
- The Influence of Caging, Bbedding, and Diet on the Composition of the Microbiota in Different Regions of the Mouse Gut. Ericsson, A.C., J. Gagliardi, D. Bouhan, W.G. Spollen, C. L. Franklin. (2018) Sci Reports 8:4065 | DOI:10.1038/s41598-018-21986-7, PMCID PMC5840362.
- Effects of Fenbendazole-Impregnated Feed and Topical Moxidectin During Quarantine on the Gut Microbiota of C57BL/6 Mice. Korte, S.W., Franklin, C.L., Dorfmeyer, R.A., Ericsson, A.C. (2018) J Amer Assoc Lab Anim Sci 57 (3):229-235, PMCID PMC5966229.
- Development of Outbred CD1 Mouse Colonies with Distinct Standardized Gut Microbiota Profiles for Use in Complex Microbiota Targeted Studies. Hart, M.L., Ericsson, A.C., Lloyd, K.C.K., Grimsrud, K.N., Rogala, A.R., Godfrey, V.L., Nielsen, J.N., Franklin, C.L. (2018) Sci Reports 8:10107. DOI:10.1038/s41598-018-28448-0, PMCID PMC6031694.
- Acclimation and Institutionalization of the Mouse Microbiota Following Transportation. Montonye, D.R., Ericsson, A.C., Busi, S.B., Lutz, C., Wardwell, K., Franklin C.L. (2018) Front Microbiol. May 28;9:1085. PMCID PMC5985407.
- Effects of Water Decontamination Methods and Bedding Material on the Gut Microbiota. Bidot, W.A., Ericsson, A.C., Franklin C.L. (2018) PLoS One. 2018 Oct 25;13 (10):e0198305. doi: 10.1371/journal.pone .0198305. eCollection. PMCID PMC6201873.
- Deficiency Negatively Impact Red Pulp Macrophages and Spleen Development in Mouse Models of Spinal Muscular Atrophy. Khairallah, M-T., J. Astroski, S.K. Custer, E.J. Androphy, C.L. Franklin, C.L. Lorson. (2017) SMN Hum Mol Genet 26(5):932-941, PMCID PMC6075362.
- Variable Colonization after Reciprocal Fecal Microbiota Transfer between Mice with Low and High Richness Microbiota. Ericsson, A.C., Personett, A.R., Turner, Dorfmeyer, G., R., Franklin, C.L. (2017) Front Microbiol Feb 23;8:196. doi: 10.3389/fmicb.2017.00196. eCollection, PMCID PMC5322181.
- Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone Inbred Mice. Toth, L.A., Trammell, R.A., Liberti, T., Verhulst, S., Hart, M.L., Moskowitz, J.E., and Franklin, C.L. (2017) Comp Med 67(2):116-126, PMCID PMC5402731.
- Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Hart, M.L., Ericsson, A.C., Franklin, C.L. (2017) Front Microbiol, 8:792, PMCID PMC5425584.
- Transforming Growth Factor-ß1/Smad3-Independent Epithelial-Mesenchymal-Transition in Type I Collagen Glomerulopathy. Brodeur, A.C., Roberts-Pilgrim, A.M., Thompson, K.L., Franklin, C.L., and Phillips, C.L. 2017) Int J Nephrol Renovas Dis 10:251-259, PMCID PMC5587152.
- Modeling a Superorganism – Considerations Regarding the Use of “Dirty” Mice in Biomedical Research. Ericsson, A.C., Montonye, D.R., Smith, C.R., Franklin, C.L. (2017) Yale J Biol 90:361-371, PMCID PMC5612181
- The RNA Binding Protein HuR posttranscriptionally Regulates IL-2 Homeostasis, CD4+ Th2 Differentiation and is Necessary for Allergen Induced Airway Inflammation. Techasintana, P., J. Ellis, J. Glascock, M. Gubin, S. Ridenhour, J.D. Magee, M.L. Hart, P. Yao, H. Zhou, M.S. Whitney, C.L. Franklin, J.L. Martingdale, M. Gorospe, W.J. Davis, P.L. Fox, X. Li and U. Atasoy. (2017) Immun. Horizons (1(6):109-123, PMCID PMC6052877.
- Doxycycline Induces Dysbiosis in Female C57BL/6NCrl Mice. Duke, F.D., Ericsson, A.C., Uchihashi, U., Dunbar, M.L., and Wilkinson, E.J. (2017) BMC Res Notes, 10 (1):644. PMCID PMC5708113.
- Sex Determines Effect of Physical Activity on Diet Preference: Associated Changes in Striatal Opioids and Gut Microbiota Composition. Lee, J.R., Muckerman, J.E., Wright, A.M., Davis, D.J., Childs, T.E., Hagan, C.E., Vieira-Potter, V.J., Booth, F.W., Ericsson, A.C., and M.J. Will. (2017) Behav Brain Res, 334:16, PMCID PMC6326100.
- Strengthening the Disaster Resilience of the Academic Biomedical Research Community: Protecting the Nation’s Investment. Agca. Y (2017). The National Academies of Sciences, Engineering, and Medicine. https://doi.org/10.17226/24827 (invited). PMCID not required (review).
- Microbiota and Reproducibility of Rodent Models. Franklin, C.L. and Ericsson, A.C. (2017) (invited review) Lab Anim (an official Nature Research Journal) 46(4):114-122, PMCID PMC5762113.
- Retrospective Evaluation of Nail Trimming as a Conservative Treatment for Ulcerative Dermatitis in Laboratory Mice. Alvarado, C.G., Franklin, C.L. and Dixon, L.W. (2016) J Amer Assoc Lab Anim Sci 55 (4):462-466, PMCID PMC4943618.
- Vaccinating with Conserved E. coli Antigens Does Not Alter the Mouse Intestinal Microbiome. Hays, M.P., Ericsson, A.C., Yang, Y., and P.R. Hardwidge. (2016) BMC Res Notes, 9:401-407, PMCID PMC4981990
- Reproducibility: Use Biobanks or Lose Them. Lloyd, K., Franklin, C.L, Lutz, C. and Magnuson, T. (2015) Nature 522:151-153, PMCID PMC4636083.
- Exoelectrogenic Capacity of Host Microbiota Predicts Lymphocyte Recruitment to the Gut. Ericsson, A.C., Davis, D.J., Franklin, C.L. and Hagan C.E. (2015) Physiol Genomics 47:243-252, PMCID PMC4491528.
- Manipulating the Gut Microbiota: Methods and Challenges. Ericsson, A.C., Franklin C.L. (2015) (invited review) ILAR J 56(2):205-17, PMCID PMC4554251.
- Isolation of Segmented Filamentous Bacteria from a Complex Gut Microbiota. Ericsson, A.C., Turner, G., Montoya, L., Wolfe, Meeker, A., S., Hsu, C., Maggio-Price, L. and Franklin, C.L. (2015) BioTechniques 59(2):94-98, PMID 26260088; PMCID in progress.
- Gut Microbial Dysbiosis Due to Helicobacter Drives an Increase in Marginal Zone B Cell Development in the Absence of IL-10 Signaling in Macrophages. Ray, A., S. Basu, R.Z. Gharaibeh, L.C. Cook, R. Kumar, E.J. Lefkowitz, C.D. Morow, C.L. Franklin, T.L. Geiger, N. Salzman, A. Fodor, and B.N. Dittel. (2015) J Immunol 195 (7):3071-85, PMCID PMC4575870.
- Differential Susceptibility to Colorectal Cancer Due to Naturally Occurring Gut Microbiota. Ericsson, A.C., S. Akter, M.M. Hanson, S.B. Busi, T.W. Parker, R.J. Schehr, M.A. Hankins, C.A. Ahner, J.W. Davis, C.L. Franklin, J.M. Amos-Landgraf, E.C. Bryda. (2015) Oncotarget 6(32):33689-704, PMCID PMC4741795.
- aTNFR2 Deficiency Acts in Concert with Gut Microbiota to Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease. Miller, P.G., Bonn, M.B., Franklin, C.L., Ericsson, A.C., and McKarns, S.C. (2015) J Immunol 195(10):4668-4684, PMID 26475926; PMCID in progress.
- Comparative Evaluation of DNA Extraction Methods from Feces of Multiple Host Species for Downstream Next-Generation Sequencing. Hart, M.L., Meyer, A., Johnson, P.J., and Ericsson, A.C. (2015) PLoS One 10(11): e0143334, PMCID PMC4657925.
- Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus. Alvarado CG, Kocsis AG, Hart ML, Crim MJ, Myles MH, Franklin CL. Comp Med. 2015;65(1):15-22. PMID: 25730753 [PubMed - in process].
- Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice. Ericsson AC, Davis JW, Spollen W, Bivens N, Givan S, Hagan CE, McIntosh M, Franklin CL. PLoS ONE. 2015 Feb 12; 10(2): e0116704. doi: 10.1371/journal.pone.0116704. PMCID: PMC4326421.
- The utility of Apc-mutant rats in modeling human colon cancer. Amy A. Irving, Kazuto Yoshimi, Marcia L. Hart, Taybor Parker, Linda Clipson, Madeline R. Ford, Takashi Kuramoto, William F. Dove, James M. Amos-Landgraf. Dis Model Mech. 2014 November; 7(11): 1215–1225. Published online 2014 October 2. doi: 10.1242/dmm.016980. PMCID: PMC4213726.
- The effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6J and SJL/J mice. Sands SA, Tsau S, Yankee TM, Parker BL, Ericsson AC, LeVine SM. BMC Res Notes. 2014 Sep 4;7:605. doi: 10.1186/1756-0500-7-605. PMCID: PMC4167283.
- Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency. Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashi, Yun-Jung Choi, Chankyu Park, Aaron C. Ericsson, Alana N. Brown, Melissa S. Samuel, Kwang-Wook Park, Eric M. Walters, Dae Young Kim, Jae-Hwan Kim, Craig L. Franklin, Clifton N. Murphy, R. Michael Roberts, Randall S. Prather, Jin-Hoi Kim. Proc Natl Acad Sci U S A. 2014 May 20; 111(20): 7260–7265. Published online 2014 May 5. doi: 10.1073/pnas.1406376111. PMCID: PMC4034252.
- Segmented filamentous bacteria: commensal microbes with potential effects on research. Ericsson AC, Hagan CE, Davis DJ, Franklin CL. Comp Med. 2014 Apr;64(2):90-8. Review. PMCID: PMC3997285.
- A Simple, Quantitative Method Using Alginate Gel to Determine Rat Colonic Tumor Volume In Vivo. Amy A Irving, Lindsay B Young, Jennifer K Pleiman, Michael J Konrath, Blake Marzella, Michael Nonte, Justin Cacciatore, Madeline R Ford, Linda Clipson, James M Amos-Landgraf, William F Dove. Comp Med. 2014 April; 64(2): 128–134. Published online 2014 April. PMCID: PMC3997291.
- APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease. Yue Yang, Eiron Cudaback, Nikolas L. Jorstad, Jake F. Hemingway, Catherine E. Hagan, Erica J. Melief, Xianwu Li, Tom Yoo, Shawn B. Khademi, Kathleen S. Montine, Thomas J. Montine, C. Dirk Keene. Am J Pathol. 2013 September; 183(3): 905–917. doi: 10.1016/j.ajpath.2013.05.009. PMCID: PMC3763765.
- A Brief History of Animal Modeling. Aaron C. Ericsson, Marcus J. Crim, Craig L. Franklin. Mo Med. 2013 May-Jun; 110(3): 201–205. PMCID: PMC3979591.
- The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research. Elizabeth C. Bryda. Mo Med. 2013 May-Jun; 110(3): 207–211. PMCID: PMC3987984.
- Development of a PCR Assay for the Detection of Spironucleus muris. Glenn A Jackson, Robert S Livingston, Lela K Riley, Beth A Livingston, Craig L Franklin. J Am Assoc Lab Anim Sci. 2013 March; 52(2): 165–170. Published online 2013 March. PMCID: PMC3624784.
- Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice. Bryda EC, Johnson NT, Ohlemiller KK, Besch-Williford CL, Moore E, Bram RJ. Mamm Genome. 2012 Apr;23(3-4):270-6.
- Theriogenology. Foreword. Agca Y. Theriogenology. 2012 Nov;78(8):1639-40. doi: 10.1016/j.theriogenology.2012.08.013. Epub 2012 Sep 13.
- Genome Resource Banking of Biomedically Important Laboratory Animals. Yuksel Agca. Theriogenology. 2012 November; 78(8): 1653–1665. Published online 2012 September 13. doi: 10.1016/j.theriogenology.2012.08.012. PMCID: PMC3939794.